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It comes from bad spelling of "Nephew." This acronym refers to a very very good friend.
Im glad Nefa is my friend.
Nefa by BoiFromDaA November 21, 2021
Related Words

down nefarious

when someone is extremely distressingly horny
aiden: Holy fucking shit. I want to bang Jessica so goddamn bad. I can't stand it anymore. Every time I go to class I get a massive fucking erection. My dreams are nothing but constant primal animalistic sex with Jessica. I'm sick of waking up every morning with six nuts in my boxers and knowing that those sperm should've been fertilized inside of Jessica's tight ass pussy. I want her to have my babies.
max: you down nefarious
down nefarious by shaftscouter December 12, 2020

nefarious 

The crimes he committed were nefarious in nature.
nefarious by Chadwin March 16, 2003

Dr Nefarious 

The Hammiest Ham to ever Ham in a Hamfest
Dr Nefarious: Possibly the most over the top villain in history and we all love him for it.
Dr Nefarious by Dastvan June 9, 2019

nefanigan 

1. A penis that appears to be in a constant state of pseudo erection.

The illusion of a nefanigan is created in some males when their package is located abnormally high upon their body.

: Oh my god, that guys package was huge! AMEEN!

: Are you kidding me!?!? He just has a nefanigan.
nefanigan by lil-K March 1, 2008

Nefarious 

Evil is just evil, but when it goes the extra mile into Bond villain territory, that's when it becomes nefarious.
She is nefarious when it comes to her friends.
Nefarious by imyourjoy April 8, 2022