A revenge seeking man who was once a very scrawny kitchen boy. He misses his dear love very much. His best friend is kind of an imbicile. Nefario enjoys cooking and coming up with master plans to steal the realm from the king. All he really wants is to find his love again. You are in for a real treat if you are friends with this guy...Nefario.
Nefario sent a message to the king.
"I miss my dear Nefario."
Nefario seeks revenge.
by The stories of Scheherazade August 22, 2017
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The Nefario Principle states that the bigger the mass of an object, the quicker the effect of a shrink ray wears off.
The larger the mass of an object, the quicker the effects of the shrink ray wear off! I call it the Nefario Principle. I just came up with it now, actually.
by Julian-does-a-lot November 3, 2022
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Dr. Nefario is the most savage person in Despicable Me, but somehow, he NEVER became the main character. There must be some conspiracy around him, because of all of this terrible treatment. He made the INFAMOUS JELLY! IT TASTES LIKE F'ING HEAVEN! HE IS GOLD, HE GETS ALL THE WOMEN!!!!!!! But still, he is treated as an extra in all the movies. THAT'S WHY HE LEFT IN DESPICABLE ME 2!!!! HE COULDN'T TAKE GRU'S CRAP ANYMORE!

He is praised in his own religion, Nefarioism. WHEN YOU SEE HIM SOMEWHERE ANYWHERE, COMPLIMENT HIS GREATNESS!!!!!!

Can also be used as an adjective for somebody very very smart.
Dr. Nefario Is beautiful.
This kid is as smart as Dr.Nefario.
by Cool Kid 102906 May 23, 2019
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A member of the Nefario gang, a group of dangerous, racist individuals who are hostile to all marginalised groups and minorities.
Tom: Did you hear that Cameron is a Nefario?
Rocky: Yeah that guy is a fucking chad.

Girl: Omg really? I wanna suck his dick.
by biggobbo September 17, 2023
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