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Someone of the male species, that wants and or appears to look like a female.A male that is very feminine, also known as a "shemale"
by Nicki November 10, 2003
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Chet: That girl looks awfully masculine
John: Haha Chet, that isn't a girl, that's a mister sister
Chet: A what?
John: A mister sister. A shemale. A tranny. You gettin' it?
by SHMOSEPH May 07, 2013
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