A saying that you use when you, or someone else, are at or just had an all time low moment. The emotional or physical pain is compared to being fucked in the ass. Not only is life treating you unjustifiably bad, it is also going to great lengths of emotional or physical destruction.
Bob: My girlfriend just told me there was someone else. Yesterday, I asked her dad for permission to marry her.
Jim: Life Is A Bitch And Sometimes It Fucks You In The Ass.
"You should just not do the dishes once to she if she will really leave you"
"really? I might as well Put my bum in the air and see if someone fucks it!"
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.