The act of one being pompous, bitchy, harsh, or unreasonable while the target individual is in a good mood and mellowed out (in most cases the usage of herb is involved).
A guy walks by and says to you "you are a wuss and I know you can't pull off that trick on your skateboard". Your response is "that dude just did some major harshing on my mellow".
Generally playing the "Devil's Advocate" when I'm trying to make a point, or irritating me into answering a question, or giving me a hard time when uncalled for.
"I was trying to eat my chalupa when this bitch came up and got up in my face about how I should be vegetarian or some shit, so I told her to quit harshing on my bus."
Boys who enjoy yaoi (a genre in Japan that contains sexual and/or romantic relations between two men); literally translates to "rotten boy"; corresponding female : fujoshi