When a simple 'fuck you' will not suffice. Used in extreme cases. Note: Use with care. An over-use of this word causes a severe decrease in its value and over all special-ness.
Tina's fiance just told her that he is leaving her for her maid of honor, Janis, will be going on their honey moon with Janis, will NOT provide child-support for his and Tina's unborn son, and that Tina looks fat in her wedding dress.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.