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It is short for different but it can be used as an noun, adjective, or verb. It’s meaning can change and has to be interpreted with context.
“Damn, LeBron James is so good at basketball. He is deefér.”

“Hey I’m thirsty, can you pass me that deefér.”

“I’m tired I need to go deefér”
Deefér by NNNDeefér September 5, 2019
Related Words
Being hungover,tired,and tripping,at the same time
I was defiebed after the hard night of partying.
Defieb by BILLY BEST June 13, 2003
When weed is vapourised and smoked through a bottle of water. It is prepared by making a small hole in a 2 litre bottle of water with a tin foil lid in which the weed is held in. The hole lets water out which fills the bottle with smoke. You then block the hole and remove the tin foil lid. Give a nice shake and inhale :)
Yes lad what you saying, going for a fat deffie at vic park g
Deffie by ColneTings February 9, 2020
man after i fucked that bitch, she made me deefle
deefle by tyler hadley May 2, 2009

Deerfield Highschool 

A highschool in the North Shore Suburbs of Chicago Illinois. A mostly all white/rich school. Everyone here ends up going to a big college and likes to brag about it. Everyone's parents spoil their kids. All the girls wear Lululemon and bring Starbucks daily. Its a good school with not the best people. Also its in a very boring town where basically nothing happens. Everyone always just goes to the city.
person 1: "Dude what school do you go to?"
person 2: "Deerfield highschool."
Person 1: "Oh that's sucks, I have a friend there and he hates it."
Person who is deaf, acceptable slang used within the deaf community.
900 deafies went to the deaf rave.
deafie by Kerb November 28, 2004