chromie homie 

The name you give to your mentally challenged friend (for they have an extra chromosome)

"Yeah I know David has autism but we're chill, he's my chromie homie"

"That special ed kid is my homie with an extra chromie"

chromie homie by TheRollexWatch November 28, 2016

Chromie Homie 

Someone with autism

“Wow! Did you know that my older brother is my biggest chromie homie?”

Chromie Homie by fffaaahanhh March 21, 2022

Chromie Homie 

An insult used against people with Trisomy 21 (otherwise known as down syndrome).

"Hey Chromie Homie, wanna get stoned later?"
"Yeah, I'm down"

Chromie Homie by PaidClover93 March 6, 2024

Homie with an extra chromie 

Person with Down Syndrome, due to the fact the condition is caused by a person being born with 47 chromosomes instead of 46.

That guy with Down Syndrome is my Homie with an extra chromie.

Homie with an extra chromie by Golden Hawk April 13, 2023

homie with an extra chromie 

That one dude who you know has your back when that autism strikes.

Autistic Child #1: I'm gonna shoot up the school
Autistic Child #1: You cool though.
Me: You my homie with an extra chromie man.

homie with an extra chromie by Phiriz January 30, 2018

The Chromie Homies 

The most powerful, super group of speeds to ever roam the world! Their quest is to rid the world of all things Gay and eViL. The Chromosomes will live on! With their Captain, The Helmet, Tourette’s, A creature known as WWW, Anyerismo, Mr.Chromtastic, Downy Boi, and The Caretaker(who is the only normal person in this stupid ass group). Together they will stop all evil and get rid of the gay(and Helseth)

Oh Shit! The Chromie Homies are here!

The Chromie Homies by YourFriendlyNeighborhoodFaggot June 18, 2018

Chromie homies

1.When your chromosomes have an extra homie
2. When you and your friends have an extra chromosome

"Hey John! Look at those chromie homies!"

Chromie homies by Edubb23 March 2, 2019