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When a person falls into a state of extreme happiness and joy when listening, seeing or talking about anything to do with the band U2 or the lead singer Bono.
He was in a state of U2phoria when he traveled 760 miles to see U2 play in a concert.

When she listens to Bono sing she falls into a psychotic U2phoria state.
U2phoria by ahlem July 4, 2011
Related Words

E-uphoria 

A discord server ran by a batshit crazy teen girl that abuses everyone she gets close to 🥰
Khaled: "Hey man wanna go raid E-uphoria?"
Chadist:"Hell yeah bruther, America!"
E-uphoria by CoChase March 28, 2021