Uncle Lou 

Uncle Lou is a vernacular term which circulates among patients and some staff (mostly volunteers) in cancer clinics. It refers to leukaemia. It is a way for patients to buffer the impact of the disease without giving it credence by mentioning it directly. It is a euphemism which is understood mostly by those who are affected with cancer, and some who treat the disease. Uncle Lou sometimes refers to a terminal condition of various blood cancers, and sometimes serious disorders of the lymphatic system, such as the Human Lymphotrophic Virus and AIDS. Uncle Lou is a way for the patient to mention the condition while distancing themselves emotionally from the enormity of the prognosis.

I'm afraid Uncle Lou's paid me a visit. Looks like he's here to stay.

Uncle Lou's moved in. I was hoping he had the wrong address.

Uncle Lou by anonymous January 31, 2023

An Uncle Louie 

A code word used to convey the desire to escape an awkward social situation.

Jack and Jill go to a party together. Jack wishes to leave with Jill due to an awkward encounter with a transvestite at the party.

Jack says to Jill: Jill I am going to give you an Uncle Louie.

An Uncle Louie by Stu846 September 17, 2007

uncle louis 

Fattest mother fucker alive with a perm, a rock hard belly, and a big 'ol cock. Also works at the VOC.

Uncle Louis has crazy eyes again... You know Steve is getting it this time!

uncle louis by Motorfoodoo December 12, 2013