TMUIU Share definition Flag Acronym for "To Me, yo(U) Is Ugly".Pronounced "Teemooyoo" Guy: Sup girl, you need me in your life. Let me get your number. Girl: Ew, TMUIU. You yo daddy's son, yah. TMUIU by yamomma March 30, 2017 0 0 Get merch Get the TMUIU mug. Buy Now — $32.95 See more merch