To drink many alcoholic beverages in a very short period of time, in order to achive a drunken state.
Karl: What you doin this weekend?
Tomo: Fuck all
Karl: Lets skull up
Tomo: Fucking oath'
by Cannons666 December 9, 2010
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A word that very few people (As of Right Now) use and is most likely known off of 'TikTok'. The saying is commonly used to let the reader know to 'Skull him up' using the "Skull (💀)" emoji as your reaction.
Ain't No way Bro is serious, Skull me Up!! 💀💀💀
by ZKM. March 14, 2022
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