Sakura Syndrome is defined in fictional works as when someone of the opposite gender is automatically hated because they are in the way of a yaoi/yuri ship.

It is based on Sakura Haruno, a character in Naruto, who comes in between the yaoi ship of Naruto Uzumaki and Sasuke Uchiha. Many Sasunaru shippers dislike her because she gets in the way of their ship.
Person A: "Why do people hate Kairi from Kingdom Hearts so much?"
Person B: "Well, partially because she doesn't help much in the plot. But partly because of Sakura Syndrome; she gets in between the ship of Sora and Riku (Soriku)."
by GoatGirlsBestGirls December 7, 2020
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Noun: Sakura Haruno syndrome is when a character of an anime is totally useless until a random part of the show, where either on-screen or off-screen their abilities somehow drastically improve and they become a main part of the show.
person 1:"Man Kagome can't do crap other then sensing those shards."
person 2:"Yeah but she does start getting useful when she learns how to shoot those arrows."

"Wow this girl was totally useless one episode ago,she must have Sakura Haruno Syndrome"
by NarutovsPein May 25, 2009
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