To toughen or "man" up. Thought up by the GameGrumps, based on the logic that ball sacs are fragile whereas pussies can "take a pounding."
"Stop being such a little sensitive dangling balls and fuckin' pussy up." -Arin, Pokemon FireRed, Episode 48
by Soapy's Image November 6, 2014
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An infectious phrase that plagues the users vocabulary, often used in place of curse words, especially freaking.
Teacher: The agricultural revolutions was so pussy up awesome. The expansion of crops made everyone say, “Wow, this is so pussy up cool!”

Student: wow, I wish I could be as pussy up smart as my teacher
by Pussyupfumper October 3, 2023
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1. Act mean towards someone.

2. Act scared/scured/cowardly towards someone.
Don't pussy up now, nigga, after talking all that shit.
by Mr. Terrence L. Trezvant September 5, 2006
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When an object or person is flat against another for protection from the elements
During the time of Pangea Italy was pussied up against Europe as if seeking protection from Africa.
by USFcrew February 22, 2009
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Mean the same that "man up" means to a mean. Means to dress up ect. and get all sexy and make men want to fuck them.
You got a pussy up.
by Judge dredd7 March 20, 2011
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Girl: ooohh beat this pussy up, daddy
Boy: oh imma beat the pussy up real good, babygirl...
by fashionista101 May 4, 2008
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she came to my house,got into m bed and i tore up that pussy...you kno i tear the pussy up
by kyred007 January 8, 2009
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