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To toughen or "man" up. Thought up by the GameGrumps, based on the logic that ball sacs are fragile whereas pussies can "take a pounding."
"Stop being such a little sensitive dangling balls and fuckin' pussy up." -Arin, Pokemon FireRed, Episode 48
by Soapy's Image November 06, 2014
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2
1. Act mean towards someone.

2. Act scared/scured/cowardly towards someone.
Don't pussy up now, nigga, after talking all that shit.
by Mr. Terrence L. Trezvant September 04, 2006
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3
Mean the same that "man up" means to a mean. Means to dress up ect. and get all sexy and make men want to fuck them.
You got a pussy up.
by Judge dredd7 March 20, 2011
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