When somebody has acted cuntishely on a frequent basis. Permacunt differs from cunt in that the reputation of said person has become so immensely cuntish that they willforever be deemed a cunt.
-"She is such a cunt, she will permanently be a cunt."
-"Yeah, man, she's a permacunt for sure."
To have permanently intoxicated yourself with alcohol and/or chemicals to such point where respectable levels of social and/or physical functioning become problematic; where you are also (quite possibly) chewing a lot.
In short, a state of complete and utter trashedness!