Optifecalosis 

The condition of having a generally crappy outlook.

She is suffering from a severe case of optifecalosis.

Optifecalosis by Dr. JFK March 9, 2021

Optirectalosis 

A medical condition consisting of a crossing of internal wiring which gives the affected person a shitty outlook on life.

John: "Life sucks."

Debbie: "You've got a bad case of Optirectalosis."

Optirectalosis by digismack April 21, 2005