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1) To open and unpackage something, generally for the first time.

2) To operate a motor vehicle in a spirited fashion.

3) To commence, or return, fire at a person or thing.
1) Hey, let's go open up that new PS3.

2) Yeah, just a few minutes ago, we had 'em opened up out there on Redwood.

3) Why don't we take the 1911 out and open up on some bottles and cans?
open up by Chingon_de_SRV December 15, 2008
To open up, as in to stab/knife someone.
The opening process can be as simple as a minor poke but generally involves heavy bleeding and multiple openings. The more insane openings consist of using your bear hands/fingers to perform the opening process.
"I finna open you up like a damn can-o-tuna, you fat slut ass biotch."
Open up by MopDawg December 30, 2003

Open Up October 

A month for people to feel free to open up to parents, doctors, teachers and so on about depression and other problems you are keeping to yourself don’t forget It’s ok to be ok ❤️

open up shop 

Verb.

1. To commence an undertaking.

2. To beat the crap out of someone.

3. To fuck wildly.

4. To turn the tables during an Ultimate Frisbee game.
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1. We should really open up shop on Project Apollo.

2. If he keeps pissing me off, I'm gonna open up shop on that asshole.

3. Dude, she's hot. I'd definitely open up shop on her.

4. We were losing pretty badly until we gave up the zone defense and opened up shop on them.
open up shop by thaks April 26, 2006

Open up a can of whoop-ass 

What 'The Rock' does.

open up a can

Popular shortened version of "open up a can of whoop-ass," a statement generally used as a threat, but can refer to a beating/act of domination that occurred in the past.
1. "If ya'll don't stop your bitchin' I'm gonna open up a can!"

2. "I'm finna open up a can on your stanky ass"

3. "The kids were so out of control I had to open up a can right in the middle of the 7-11!"
open up a can by naborsG January 14, 2006