my main 

The definition of my main to me is when she your best friend and when she stand by you when you need help

Jennifer: You stood by me when i needed you
Sarah: I would always be there for you you are my main

my main by MybabyGirls May 22, 2016

my main 

Another word for bff or #1 friend or ride or die

Sarah: You been my main every since kindergarten
Jazmine: You and Keke been #1 friends since 1st

my main by 2~Cute~4~U March 20, 2015

My main 

Another word for best friend. There isn't really a difference with it

"Is she ur main???"
"YAS SHES MY MAIN SHES THE BEST PERSON EVER 🥺💖"

My main by JustMissie March 2, 2022

My Main Nigga 

My Best Friend

Can also be used in context when referring to whom you often drink, smoke, or on occasion Eiffel Tower with.

Shit. There's my main nigga John. We gonna get drunk, smoke da chronic, and eiffel tower dat bitch over there. Fo free!

My Main Nigga by Tom da Bom June 15, 2008

My Main Bitch

That one fucker you're stuck with for the rest of your life because they know far too much for you to just be casual friends
Much like a parasite you are one in the same being except a main bitch has better taste in movie trivia

Check it, here comes my main bitch, gotta bounce :)

My Main Bitch by Salimas-main-bitch June 20, 2016

my main squeeze 

Your best friend, home skillet, buddy for life, homie home dog, home skillet biscuit, friend for life,usually of Mexican heritage, around 5 feet tall, often named Andrea because you guys are BFFS and he/she is the real MVP. All in all, your uber duper extra best friend.

Yo that girl Andrea is my main squeeze, we been friends since all the way back in 2010

my main squeeze by Thugmaster3k October 7, 2015

My Main Man Derek

legit my main man derek

yo, it's my main man Derek!

My Main Man Derek by Xocrone May 11, 2020