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A genetic disorder resulting in physical deformities that render totally useless super powers.
That guy with the double thumb can pick his whole nose as a result of his mutantism.

Little Jack Horner

Sat in a corner

Eating a pumpkin pie

He put in his double thumb

And pulled out two plums

And said

"Oh, what a good mutantism boy am I!"
by Logic Ha January 21, 2010
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