Rachel: Have you seen this meme? If you squint it looks like John.
Amy: I don't have to squint before you said that I thought it was John.
Rachel: Do you think it could be him? He's been memified!
To be emasculated, either imediately or over a period of time. e.g. dressing like a woman or being on the receiving end of a strap-on or generally being the bitch in a relationship.