by Aeh1234 December 22, 2020
The disease known as Luke syndrome is when people are poorly baised toward you for no particular reason and prefer what you do when other people do it for no reason.
"Mom would rather have you do the laundry than me even thought we do it the same way, I must have Luke Syndrome!"
by Fishy663 September 27, 2021
When a mid-30s actor or actress portrays a teenage character in high school. Named for that ancient actor portraying Dylan on 90210
I was watching 21 Jump Street and that guy Frederic Forrest played a teenager, but he was balding and had a beer gut. He totally suffers from Luke Perry Syndrome
by GenePoole February 23, 2009