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Sex for its own sake; when one or both of its participants doesn't want or doesn't know if they want a committed relationship but are horny. Usually, sex early on, especially on the first date, is the hallmark sign of a hook-up.
Dude 1: How'd your Tinder date go last night?

Dude 2: Pretty good. We got dinner and drinks and went back to my place.
Dude 1: Nice! Did you hook-up?
Dude 2: Yeah, dude. She was pretty hot.
Hook-up by JayMoolah September 17, 2017
1. Your drug connection.
2. To get with a honey.
1. "Yo, can I meet yo' hook-up?"
2. "Me and that fine-ass bitch gunna hook-up."
hook-up by Diego September 4, 2003
When people Hook-up, it having sex. most of the time with no stings attached
Boy:wanna Hook-up?
Girl:okay
*insert sex here*
Never talked to eachother again
Hook-Up by MasterOfTheWicket April 23, 2007
When some ass hole comes along, you give him oral and he ignores you for the rest of his douche life. And you die with disguat every time you see him.
Guy:Hey bitch get over here
Girl:what?
Guy:Get over here and give me head
Girl: Okay i guess i have nothing better to do.
they never talk to each other again

i hate hook-ups
hook-up by Mollygurl January 6, 2008
"Intentionally Ambiguous" - literally
Phrase is intentionally misused when talking about the relationship between two people.
hook-up by JMCI July 6, 2005
A hook up is a large concoction of food made in either prison or jail, with items provided by the jails commisary (made/eaten aside from the 3 meals the institution provides you). usually couple packs of ramen noodles. cook em, drain em, add chips or cheetos and a packet or 2 of Cactus Annies chelese squeeze. mix it all up. (also add "Lil Dudes", or pepperoni or summer sausage. Making Sandwitches out of this noodle conconction is very common. Usually only made or consumed when your in Jail/Prison from their commisary.
"yo n*gga i got 2 soups and a lil dude, u wanna get some chips and cheese and make a Hook-up?, that lunch was nasty"
Hook-up by bansheebot129 March 7, 2013