Holy Hoppin' Hemoglobin! Share definition Flag A phrase to express surprise, anger, or resentment. "Holy Hoppin' Hemoglobin!" shouted Franklin as he was impaled. Holy Hoppin' Hemoglobin! by Blahmaster Whinehander March 25, 2004 0 0 Get merch Get the Holy Hoppin' Hemoglobin! mug. Buy Now — $32.95 See more merch