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Holy shit, Jesus fucking Christ! What the fuck!?! 

A response to someone who is/was doing an action that is morally wrong, such as murder.
Holy shit, Jesus fucking Christ! What the fuck!?! You just killed the man!

Holy Shit Fucking Mushrooms 

when shit is so out-of-hand that you are tripping balls, i think
it's what the scientists from Far Cry 3: Blood Dragon say when things go haywire
Holy shit fucking mushrooms! There goes Chernobyl Reactor No. 4!

Shit Fucking Holy 

When something already is, or is becoming, so much better than imagined, then it be gettin fuckin holy
Guy With Donuts: “Guys, it’s Friday!”
His Bro: “Finally, shit fucking holy!”

holy fucking shit 

An exclamation of surprise, exasperation, indignation and wonder.
Holy fucking shit, Hillary said she's running in 2004.

Holy Fucking Shit 

HFS: An acronym standing for Holy Fucking Shit, mainly used for things that require more than just a "Fuck" or a "Shit."
Person 1: Bro someone left a huge dook in the toilet bowl!
Person 2: HOLY FUCKING SHIT!