Rare, jungle venerian disease created by Paris Hilton and her promiscous sex life. Combination of Gonorrhea, Syphilis and AIDS, sometimes herpes: herpetic gonosyphilaids.
Emily: Hey bestie did you hook up with Matt last night?
Maggie: Dude, we hooked up a wee bit and then my vag was burning and now I have the holy trinity of Gonosyphilaids.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).