Depakote Valproate (VPA) and its valproic acid, sodium valproate, and valproate semisodium is an anticonvulsant. It can treat seizures and
bipolar disorder. It can also help prevent migraine
headaches. Depakote can treat
depression and anxiety. It lifts your mood and reduces anxiety. Proposed mechanisms include affecting GABA levels, blocking voltage-gated sodium channels, and inhibiting histone deacetylases.