A Jojo reference 

A reference to Hirohiko Araki's long running manga (and anime) series Jojo's Bizarre Adventure. Usually pertaining to things simular to or referencing Jojo's Bizarre Adventure themes such as floating or exploding Kanji, posing that covers the face and aesthetic of both the show and manga.

Hey Bob was posing at the business meeting today with his hands and hips. Was that his arthritis or a jojo reference?

A Jojo reference by HentaiExpert August 30, 2017

A Jojo Reference 

Basically anything that comes out of a persons mouth

Person: *breathes*
WeeB: OHMYGOSH IS THAT A JOJO REFERENCE?

A Jojo Reference by Random homo sapien August 10, 2019

A jojo reference 

Jojo reference

A:Ora
B:HOLY SHIT IS THAT A JOJO REFERENCE!?!?!?!?

A jojo reference by Bunhat October 17, 2018

A Jojo Reference 

A Jojo reference is a reference to something in the Jojo's Bizarre Adventure Manga. Sometimes, people make Jojo references on accident, or on purpose. Like someone saying "I refuse." with the Rohan face, Or making a donut Joke.

Non-weeb: -Accidently does a Jojo reference without knowing-
Jackson: Is that a Jojo reference?
Non-weeb: Who the fuq is Jojo.

A Jojo Reference by Kakyoin Noriaki September 24, 2020

is that a jojo reference 

This phrase is usually said when a person or group makes a comment or question that refers to a element from jojo's bizarre adventure.

Guy 1: "Ay dude i ate a slice of bread"

Guy 2:"IS THAT A JOJO REFERENCE"

is that a jojo reference by God of the defs June 21, 2020

not a jojo reference 

but not a Jojo reference, IS A JOJO REFERENCE

guy 1:Is that a Jojo reference?
guy 2: of course not dumbass
guy 1: but not a Jojo reference IS A JOJO REFERENCE

not a jojo reference by Fletchinder Jojo dude March 3, 2021

IS THAT A JOJO REFERENCE?! 

Often used by 12 year old JoJo fans, This Phrase can be used to communicate one's delinquency in public, like a mating call for other 12 year old JoJo fans.

*Giorno's Theme Plays*
12 Y/O JoJo fan: IS THAT A JOJO REFERENCE?!
19 year old attractive female tiktoker: No lol it's from tiktok.
12 Y/O JoJo fan: *pulls out DSR-Precision DSR 50 Sniper Rifle*.

IS THAT A JOJO REFERENCE?! by JOJOFAN12345 October 31, 2021