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1st Round Knockout 

A manuever that takes place in the early, unsuspecting hours of the morning where a man positions his crotch over the face of the victim, pulls his morning wood down towards his toes and releases it like a catapault . This strike hits the "opponent", obliterates their jaw, and results in a sound resembling a knockout or similar hard hit in a fight.

Most commonly used at house parties, fraternity houses, and bedrooms as punishment to humiliate a person such as an uninvited guest, a tool, or irritating girlfriend who has pissed you off. A quick and easy way to get revenge or show disapproval.
"Last night at the party, Brandon passed out on the couch with his shoes on so Frank woke him up this morning with a 1st Round Knockout."

"Why's Lisa's chin swollen?" "She was a complete cunt to me last night so I got up early this morning just so I could pay her back with a 1st Round Knockout"
"Spiderman her next time"
1st Round Knockout by Wildman Bill September 11, 2009

1st Round Draft Pick 

Any top notch female worthy of being your main woman
"Sandra is ok, but her girl Tangela is a 1st Round Draft Pick"

1st rounder 

A star player that was drafted with the intent to carry an entire team on his back, but Is more interested on the off field advantages of being a stud athlete.
Jay Cutler is the OG 1st rounder. So much talent, but man, that guy does not Careeeeee about fucking anything!

It finally looked like the team was destined for a championship, but their two new 1st round draft picks Swede and Levi just wanted to be 1st round booze bags.

That devin kid just doesn't have what it takes to be a 1st rounder. No wonder he ended up as a sophomore year walk on when the team lost 4 players to the meazels.