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Not equal to.
=/= by dj gs68 July 23, 2003
to squint at someone when they have done something wrong or if they are going to do something wrong
Fred: i ate the last piece of cake...

Samuel: =.=
=.= by kdlfn October 7, 2010
An annoyed face often used in chat. Similar to -_- but a little more annoyed. More of a squint, or glare.
Person 1: lol you suck!
Person 2: .... =_= shut up
=_= by BaldDumboRat September 9, 2008
A smiley derived from anime. Use to define exhaustion, or age.
Uhh... I'm tired. =_=
=_= by KamikazeH2OMelon September 25, 2005
An expression used during a chat etc, to express that you are tired...
A - "Man this weekend sure will be fun!!"
B - "Lucky for you...I have heaps of work to do...=.="
=.= by Sukari March 19, 2004
An emoticon, meant to look like narrowed eyes, used to show one is suspicious of another's claim(s) or motive(s).
Markus_Capricus: dude Candice will give you a nude if you ask
Markus_Capricus: almost straight away
Mercutio676: =-__=-

BobOnHisRocket: send me sum pics of ur fam?
Blastoise15: =-__=-
Blastoise15: Why?
=-__=- by Regolith June 19, 2013