duff

as in to bone a chick. to get duffed out

i duffed this sweet dude last nite yeahhh!!!

by gap slammer November 7, 2006

DUFF

Designated Ugly Fat Freind

Jim: Bob you are my designated ugly fat friend (DUFF)
Bob: I'm not that fat!

by z108108 February 18, 2015

duff

The stuff left on the bottom of your weed bags. All the stems, crystals, and leafs. Often used as a cheaper alternative to buds in baking. Though often mistaken as good, and used in joints and bowls. Known to be sold for as cheap as 30-40 dollars an ounce.

Hey bro, got any of that duff? I need to make another's batch of weed brownies.

by fitzy_keegs January 13, 2017

DUFF

Dumb ugly fat friend

That dude is the duff of the friend group

by Tiasg March 8, 2015

duff you in

Meaning to beat some one up, to knock some ones ed off or to generally slap them about

For example I will duff you in when you get home cory

You deserve a propa duffing

by Bobz1992 February 7, 2014

Duff

Designated Ugly Fat Friend is a person that you keep around to be more attractive and popular also known as the D.U.F.F

Two hot girls are sitting with a ugly girl. I feel bad for that Duff.

by Alize Marie September 21, 2017

Duff

V. To plan a sexual encounter and back out soon after, to stand up.

He said he wanted to be with me, but then he duffed out and changed his mind.

by Laurie-Bell February 1, 2009