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He was so tweaked that he didn't know whether he was coming or going.
tweaked by Billy March 11, 2003
Related Words

Twacked, cracked and totally wacked 

A gtarded tweeker who no longer can differenciate between fact and fiction. You will usually find them naked hiding from the imaginary cops or ninjas that are out to get them.
Is the poor girl still dating Jonathan? No man, he is sure twacked, cracked and totally wacked.
To get twin fucked/to get fucked by twins
“That girls about to get twucked.” -tina
“why?”-chris

“because the twin brothers both want to fuck her.” - tina
Twucked by JudyTrudyGotABigBooty September 24, 2018
Twacked is the term that describes coming down from amphetamines after the more pleasurable effects have worn off. After that amazing feeling, the one where every word that comes out of your mouth feels like it's made of silver, the feeling where your every thought and emotion become the most important thing in the world, or when you feel like all of your buddies are clinging to your every syllable like it's their life support (and you do the same to theirs).

It's that amazing feeling but the complete opposite.

Every word is forced, every thought muddy and brown, your friends no longer seem to have any concern for you, your tired but you cannot sleep, your hungry but eating brings only the feeling that your swallowing a whole apple, this is being twacked. When your twacked you become nothing more than a zombie. You have no soul or feelings. In this state your emotions are brown and muddy, usually non-existant.
Although I've never tried meth or speed. I have been twacked after nights of more adderall than I can count. Being twaked is an amphetamines equivalent of a hangover. It's the reason I've never bought adderall and have only done it on occasions where it was free. It's the reason I'll never try meth. It's the reason my preferred amph is XTC. It provides the greatest sensation of ecstasy (hence the name) with the most tolerable come down.
twacked by ~~Smoke weed every day~~ December 30, 2007

tweaked out 

A person typically and habitually under the influence of cocaine, methamphetamine, diacetylmorphine, and any other tweaker choice you could think of.
Bob: Hey Jimmy see that guy over there?
Jimmy: Yeah man, he's acting pretty weird.

Bob: Eh, must be tweaked out or something .
Jimmy: On the real lets keep movin.
tweaked out by Burberry Hilfiger January 16, 2016

twacked out 

Being twacked out is when you're on tweak and you're freaking out. Tweak is also known as ice, glass, crank, or most commonly, crystal methamphetamine.
Person A: "Dude, chill out!"
Person B: "Man, I'm totally twacked out." (Sitting there, picking at his skin/looking out the blinds/rocking back and forth)
twacked out by Fool June 19, 2006