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A methamphetamine user. Tweekers are known for their extreme paranoia, flagrant dishonesty, and lack of non-tweeker friends. A tweeker will steal your stuff and then help you look for it.
If you let those god damned tweekers come to your party, don't expect to have your stereo in the morning.
by josh@rootpoot November 25, 2003
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Nov 27 Word of the Day
A stupid person; it refers to the lack of surface area on an individual's brain. The general thought is that the more surface area (wrinkles, creases, etc.) a brain has, the smarter the person is. Conversely, a person with a smooth brain (no wrinkles) has less surface area and would therefore be stupid.
That fucking smooth brain put his shirt on backwards again...

That smooth brain is dumber than a pile of shit.
by Tip Tank May 14, 2011
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2
A methamphetamine user. The term was coined for the sleep deprivation crystal meth addicts usually undergo. Some users would stay up for two weeks at a time so came the phrase 'two weekers' which eventually became tweeker.
Its been days since that guys gotten any sleep or had something to eat.. he's gotta be a tweeker.
by jeff! August 10, 2005
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3
He might be doing a little coke, but he's way too fat to be a tweeker.
by Village Idiot May 21, 2012
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4
People who smoke to much crack and get paranoid about there phone getting tapped or someone breaking into their house through the roof.

The ones that start shitting on their friends and fam for their habbit are just called Shit Cunts....
Hahaha look at the tweeker in the window!!! Hahaha

Shshshsshsh... did you here that.

I think that bitch is talking about me!
by Vortex78 August 17, 2016
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5
Any poor soul who has the bad ass luck of growing up in a small depressed desert town in CA or elsewhere who is emotionally addicted to CRYSTAL METH. They will kill and die for it, and can never be cured. They will want it every day for the rest of their lives. They start by doing lines, then smoke it, and eventually they graduate to "slamming" using needles. At this time, they never want to see anyone, unless they are tweeking. They are afraid of everything, except death. All of their friends are parolees, and they aint shit until they have been to prison at least once. They steal everything in sight, draw sexually explicit pictures, talk shit, disapear for days or even weeks, will physically assault the people they love, slash their own wrists and arms. They will lose up to 100 pounds in a few years. They will have spent all of their money and lost any job they might have once had. They are unemployable. They hate themselves. They will spent 5 to 40 hours straight beating off and sticking things up their asses. Some will steal panties from the apartment dryers and wear them. They will eventually accomplish self fellatio! Anything is possible with speed!!!
"Tell your tweeker friend to get the fuck out of my bathroom!"

"Palmdale is all about the tweekers. The Sherriffs do it too."

"I heard his mom tweeks with him every time her check comes."

"Dude, stop tweeking out on it for a while, They get the point, damn!"
by Alumni September 14, 2005
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6
A person who spends countless hours performing repetitive tasks while high on amphetamines or methamphetamines. Usually they hide during the day, away from the public because of the schizophrenic state and horrible complexion caused by days of sleep deprivation and not eating.
Look at that tweeker, his face is covered with scabs because he picked at his skin for hours without even thinking about what he was doing.
by CT August 22, 2003
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