Adjective

-Showing signs of beeing stoned,when you havent ever even touched a bag or leaf of pot, acting stoned talking like your stoned,walking like your stoned,and thinking like your stoned.
A: Dude you are so incredibly tweeked its not even funny.
B: Huh, Huh..wait.. wut?

X:Hey you two, i dont want you tow crazy hippie stoners haning around here anymore!
Y: Oh no mr.wong we're not stoned we're just tweaked.
Z:Yeah man, totally umm like totally nothin to worry.uhh whats that word a ground around..uhh dammit i cant remember.
Y:ha ha hah ah, dude i think your trying to say about..hehe lets go get a milkshake
Z:sweet to the max
Y:later dude
X: crazy stoners...
by mcbar May 8, 2005
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to be forced into smiling by infectious enthusiasm and boundess energy
you've been tweeked, i was at a low until i got tweeked
by gsxrboy June 2, 2007
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This is a character for a TV series named "SouthPark" This character is twitchy and is always drinking coffee and blurting our noises and conspiracies. He is also in a homosexual relationship with Craig Tucker after tons of people loved the slash so the creators made it happen.
Craig: You should stop drinking coffee Tweek.
by IsYaBoiSam May 1, 2016
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Verb. A side effect of extreme over indulgence in crystal meth or crack cocaine. Tweekers typically perform OCD-like activities centered around finding small quantities of drugs that were inadvertently "misplaced". Tweekers may be seen on all fours, searching in gutters, obsessively looking under various objects and so on. In certain circumstances, extreme tweeking resembles autism or catatonia.
by Slagathor April 23, 2004
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A character from the TV show "South Park". Tweek is the ADD kid, who is constantly twitching. He often rants and raves about things that only he sees, and is addicted to coffee. Tweek is in love with Craig, and they sex each other.
Wow. Tweek sure has sex with Craig a lot. It's hot.
by The Lord Of Spam February 17, 2006
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the state of mind when using methamphetamines that the user cannot stop doing an activity and has been up for days.
Man i was tweeking hard after cleaning for six hours last night.
by Tweeker July 17, 2003
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