Duff 

Dumb Ulgy Fat Friend. The one friend that people only talk to to find out info on their hot friends

I want to find more stuff out about Nikki. I'm going to ask her Duff

Duff by thatonegirl3000 March 8, 2015

duff 

consumimg cannabis sativa by means of smoke.

wrestling is coming up soon it's about time to duff

duff by d-boy April 30, 2003

Duff 

to spill something on your clothes.

I duffed my coffee this morning during the commute.

Duff by Argh Dammit September 25, 2005

Duff 

1.A incognito way to compliment a nice behind without being heard or looked at by the selective the female target.the term started in NJ in the summer of 2007 and is now being used by college students,frat brothers and perverts up and down the east coast!

2.Nice Big round mound of butt that defies the laws of physics.

1.Jimmy have you seen "Billy Duff"? (while pointing out a target)
2.I was strolling down the beach earlier and saw a "Duff".
3. "Duff" to the right!
4. That's quite a large "duff".

Duff by Joemy mckenzanela November 19, 2010

Duff 

designated ugly fat friend

"Your their Duff, they are prettier than you"

Duff by heyo2 May 30, 2015

DUFF 

When you see two hot chicks hanging out with a fatter, uglier woman you can pinpoint this woman as 'the DUFF'. DUFF stands for Designated Ugly Fat Friend. Hot chicks usually have a DUFF to make themselves look even better, when compared to their DUFF.

"That DUFF will make anyone look good."

DUFF by SmartyTarty September 23, 2015

duff 

An awesome lay.

'I just had Duff ..... and it was the best sex ever' !!

duff by Eeevil March 14, 2003