When someone comes over to smoke pot with you and then leaves right after, typically giving a stupid excuse as to why, as opposed to staying and chilling.
"man, i think joe just used us to smoke some bud."
"yeah dude, that was a hit and run."
Usually an exclamation that indicates that something is extreme such as surprise, wonder or anger. Also any other emotion, thought or action that is thought to be extreme.
Mike was so high one time when he was smoking some weed he said "Hit Yo! That's some good weed!"
Another technique used by office placebos, when in for a long presentation, the placebo early on, say in the first 5 minutes drop the initial hit-and-run question, which leads everyone (boss/presenter) to believe he's engaged ... this quick hit allows him to run, slip out, disengage for at least the next 30-45 minutes
Jackson : Boy Adam, I hope my hit-and-run question worked, I really need to slip out of the presentation ... I've got lunch plans with Sophi.
Murphy : Don't worry Jackson, I'm pretty sure it did... didn't you see how Miller took notice, he loves when someone from his team speaks up.