To have intoxicated yourself with alcohol and/or chemicals to such point where respectable levels of social and/or physical functioning become problematic; where you are also (quite possibly) chewing a lot.
In short, a state of complete and utter trashedness!
adj. Long, wiry and muscular build prone to squirming and writhing, similar to the build of the order mustelidae, consisting of weasels, ferrets and badgers.
This mustelidous baby is gonna squirm right outta my hands!