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When an optical computer mouse's pointer decides to fly off into a corner of the screen without your consent.
"I can't find my cursor, my mouse must have derked."
Derk by southparkrox September 21, 2009
Related Words
Computer geeks cannot pronounce words of more than one syllable therefore Derek becomes Derk. Derk is the formal form but can be malformed further into Derkio when geeks want something Derek has, this is usually edible items eg cake or orange flavoured kit-kats.
Derk by minerva1961 April 6, 2010
shortened form of derek, one who enjoys constant douchebaggery, qualities can be compared to that of a taxi driver
"yo you derk! drive me to that party!"
"ok, but pay me for gas i only get half a mile to the gallon"
derk by antzpowah69696 August 17, 2009
A short person with a big with a big butt, who likes to have pirate fights with Scooter in his jungle. They also like eating chicken while looking at flowers and playing Halo 5. They bake good cakes and annoy Lulu. MAKE GOOD WIVES.
(Only cool people are derks)
I'm a derk, you're a derk, we're all derks.
Derk by MariaDerk and KatieDerk April 12, 2013
A word mixing the common insults; dick, dork, and jerk together. A derk is usually used to describe an annoying or agitating person/place/thing.
That guy is such a derk.

It was like walking into Derksville.
Derk by BananaMonkey123 February 22, 2008
To dip from the police/parents/anyone worth running from
Originated by a local DJ in the 925
Joey Cerletti AKA DJ Joey C
O fuck my parents are home, DERK!

Holy shit, its the cops, we gotta derk it.
Derk by DJ Joey C February 28, 2008