twotsmacker Share definition Flag A female cockblocker ,one who prevents the sucking of a penis. A girl who stops the hooking up of a fellow vagina What a twotsmacker, danielle is with her boyfriend and she just did that!!!!!!!!!!!! twotsmacker by CHILD PUNTER May 26, 2009 0 0 Get merch Get the twotsmacker mug. Buy Now — $32.95 See more merch