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the state of mind when using methamphetamines that the user cannot stop doing an activity and has been up for days.
Man i was tweeking hard after cleaning for six hours last night.
by Tweeker July 17, 2003
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To be in paranoia or panic
"Dude, no one is talking about you so stop tweeking."

"Just because you're alone it doesn't mean someone is watching you, so stop tweeking."
by Melisha June 25, 2005
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To zone out while on drugs.
"Man, look at him hes tweeking right out !"
by Josh January 2, 2005
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Tweeking: A combination of two words, two and week. When you have been on meth (cranking in the old days) and up for two weeks you have a tendency to talk funny and slur your words. After two weeks when you try to tell someone what your problem is all you can say is "I tweek..." After coming down for a day before your next trip you realize that you said tweek and also realize that it is not only a homonym with tweak, which means to bend or force out of shape, but it can also be synonymous. And since you were very bent you think it is funny and go get an eightball, and your again tweeking in no time at all. This is the origin of the word, believe me I was there.

Moral of the Story: Don't do drugs
Pleeezzzze hlp ma, I tweeeeeeek blaaargghhh *thump*
In the next day or two after your regain consciousness you say; "Man I was tweeking."
by cawper January 9, 2008
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An act of picking on someone caused by anxiousness for another high.
If you catch anyone tweeking, they're drug of choice is controlling 'em.
by Mr. Terrence L. Trezvant June 4, 2007
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This is a character for a TV series named "SouthPark" This character is twitchy and is always drinking coffee and blurting our noises and conspiracies. He is also in a homosexual relationship with Craig Tucker after tons of people loved the slash so the creators made it happen.
Craig: You should stop drinking coffee Tweek.
by IsYaBoiSam May 1, 2016
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