Verb. A side effect of extreme over indulgence in crystal meth or crack cocaine. Tweekers typically perform OCD-like activities centered around finding small quantities of drugs that were inadvertently "misplaced". Tweekers may be seen on all fours, searching in gutters, obsessively looking under various objects and so on. In certain circumstances, extreme tweeking resembles autism or catatonia.
by Slagathor April 23, 2004
A character from the TV show "South Park". Tweek is the ADD kid, who is constantly twitching. He often rants and raves about things that only he sees, and is addicted to coffee. Tweek is in love with Craig, and they sex each other.
by The Lord Of Spam February 16, 2006
by chillcat May 29, 2003
the nervous ticks or twitching one experiances as they come down from a crystal methamphetamine binge.
by a former tweeker November 28, 2003
A character from the T.V show "South Park". He has very messy blonde hair and supposedly sufferes from A.D.D but his twitching and nervous personality is due to the large amounts of caffeine he consumes. In Series 6, Tweek became the main characters replacement for Kenny, alongside Butters, after he "permeanantly" died at the end of the previous series.
by Issy Aidsfunop January 15, 2006