Verb. A side effect of extreme over indulgence in crystal meth or crack cocaine. Tweekers typically perform OCD-like activities centered around finding small quantities of drugs that were inadvertently "misplaced". Tweekers may be seen on all fours, searching in gutters, obsessively looking under various objects and so on. In certain circumstances, extreme tweeking resembles autism or catatonia.
by Slagathor April 23, 2004
A person that appears to be on any controlled drug or any street drug. altering their mind in an overly dramatic way.
He/she comes to work everyday high, appears to be on some mind altering drug. Acting over dramatic about the smallest things. this person is tweeking
by ColdOneOnly January 22, 2017
A character from the TV show "South Park". Tweek is the ADD kid, who is constantly twitching. He often rants and raves about things that only he sees, and is addicted to coffee. Tweek is in love with Craig, and they sex each other.
by The Lord Of Spam February 17, 2006
by chillcat May 30, 2003
the nervous ticks or twitching one experiances as they come down from a crystal methamphetamine binge.
by a former tweeker November 28, 2003