totes deff Share definition Flag another way of saying most deff, fo sho, or of course. it originated from clint but was then spread to south florida by nikki Meghan:"Paul's ass is huge" Nikki: "Totes Deff!" totes deff by NikkiHuts May 21, 2008 0 0 Get merch Get the totes deff mug. Buy Now — $32.95 See more merch