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A girl with a heart of gold. She always cares more about others than herself (even if she doesn't show it she still does) and she will try her absolute best to help you. She has a smile that lights up a room but her laugh is something else.... She will always make you smile and never intentionally put you down. She's always up for a challenge no matter how hard and fangirls over people like crazy. If you meet one... don't let her go!
Person A - Who's that girl with the nice smile?
Person B - That's Santiana
Santiana by yodefsaremine July 11, 2017
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When a person inside a school has very erect nipples.
Briones had santiana's. LOL OMG11!!!
santiana by Regobilly February 1, 2008
Santiana is a very funny girl, she is really pretty and always smart. Her sister may be mad all the time but she never lets that stop her and she keeps going. She is also a BADDIE! DO NOT PLAY WITH THE BADDIE SHE WILL BEAT YO ASS SO SIT TF DOWN. Anyways, i love her!
Santiana is so funny!
Santiana by Santiana (pretty) December 6, 2024

santana lopez 

THE QUEEN OF LIMA HEIGHTS.

and also the character who insults everyone and keeps you entertained when you have absolutely no hope in the show.
person 1: who’s that girl who sang trouty mouth? she popped off

person 2: santana lopez of courseeee!!!!

Santana Lopez 

the hot lesbian from the tv show GLEE
“Hey did you hear Santana Lopez is a lesbian??”
Santana Lopez by jadeallisa November 16, 2017

fredo santana 

The scariest rapper ever... He has a cross tattooed on his forehead and when he in da cut its a scary sight..
Dat nigga a fredo santana...

He almost as scary as fredo santana...
fredo santana by 808mafia December 25, 2013

Santana DVX 

Just some positively fly bubbly brought to you by Carlos Santana. Santana DVX is the preferred beverage of The Lonely Island, and is name-checked in many of their songs.
Tim: I can't believe Santana DVX is only $5.95 a bottle!

Eric: Must be a sale.