A unisex name but mostly used for males. Santana is person who is extremely intimidating but lit once you get to know him/ her. Santana does not take BS. He has impeccable style. And is also intelligent and talented.
Santana is so attractive.
by Boujee Santana June 3, 2021
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The second worst Pillar Man from JoJo's Bizarre Adventure Part 2. Known in some translations as Santviento. For those wondering, the list of the Pillar Men from best to worst is as follows:

1. Wamuu
2. Esidisi
3. Santana
4. Kars
Joseph: Your next line is, "Learned your lesson, primitive?"
Santana: Learned your lesson, primitive?
Santana: ...!
by NamesAO August 15, 2018
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The best guy you’ll ever meet. He’s caring and super funny with the ability to make any day better. People call him all the time just to calm down. Super hot with a body as amazing as his personality. With perfect brown eyes and the best lips imaginable, you’ll want to kiss him for hours on end just to be near him. Santana’s are one of the most special things in life so if you find one, you better keep him.
Girl 1: Damn, see that Santana over there?
Girl 2: Back off he’s all mine
by kaybae19 July 15, 2018
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The most perfect girlfriend you could ever find. Great smile. 10/10. Never let her go because you're definitely going to regret it later in life.
1st girl: Damn is that a Santana with my ex?
2nd girl: Shit, you just lost the ex game.
1st girl: *Starts crying*
by Bluebro11 July 29, 2016
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Meaning holy or a saint like follower of Christianity
Santana is a follower of Christ
by Real95 December 21, 2016
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Santana as in "Saint-Ana". Sanatana means a saint very holy and clean. Originated in spain;
Carlos Santana, guitar player; Juelz Santana aka. DipsEt, rapper.
by Jezebel Santana December 7, 2007
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a kickass guitarist that combines blues rock and latin music in one
did Santana ever play with Jimi Hendrix?
i wish it, that would've made someone jizz theirself if they ever heard that song
by D money 9295 August 20, 2010
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