A ride-or-die chic who always tells it like it is. She's loyal til the end to those who are loyal to her. She has long dark hair and dark piercing eyes that has the ability to stare right into your soul. She's one of the hottest bitches on the block and she is what every man dreams of. She's got the whole package once you have her you don't want to ever let her go. Santana is a freak when the lights go out once you have had her you'll never forget her and you won't never find another like her even if you search far and wide she's one of a kind.
That's Santana and she is a down ass bitch she been A1 since day 1.

I can always count on Santana when I need her.

Damn Santana got that good good.
by Mind-Wonderer October 17, 2016
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The best guy you’ll ever meet. He’s caring and super funny with the ability to make any day better. People call him all the time just to calm down. Super hot with a body as amazing as his personality. With perfect brown eyes and the best lips imaginable, you’ll want to kiss him for hours on end just to be near him. Santana’s are one of the most special things in life so if you find one, you better keep him.
Girl 1: Damn, see that Santana over there?
Girl 2: Back off he’s all mine
by kaybae19 July 15, 2018
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The second worst Pillar Man from JoJo's Bizarre Adventure Part 2. Known in some translations as Santviento. For those wondering, the list of the Pillar Men from best to worst is as follows:

1. Wamuu
2. Esidisi
3. Santana
4. Kars
Joseph: Your next line is, "Learned your lesson, primitive?"
Santana: Learned your lesson, primitive?
Santana: ...!
by NamesAO August 15, 2018
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The most perfect girlfriend you could ever find. Great smile. 10/10. Never let her go because you're definitely going to regret it later in life.
1st girl: Damn is that a Santana with my ex?
2nd girl: Shit, you just lost the ex game.
1st girl: *Starts crying*
by Bluebro11 July 29, 2016
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A unisex name but mostly used for males. Santana is person who is extremely intimidating but lit once you get to know him/ her. Santana does not take BS. He has impeccable style. And is also intelligent and talented.
Santana is so attractive.
by Boujee Santana June 3, 2021
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Meaning holy or a saint like follower of Christianity
Santana is a follower of Christ
by Real95 December 21, 2016
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Santana as in "Saint-Ana". Sanatana means a saint very holy and clean. Originated in spain;
Carlos Santana, guitar player; Juelz Santana aka. DipsEt, rapper.
by Jezebel Santana December 7, 2007
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