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When a person you are dating/hanging out with suddenly disappears with no warning and/or without a trace. Derived from the way Punky Brewster's mother abandoned her on the TV show by saying she was "Going to the store for a minute" and never came back.
Mike: So hows things going with that girl?

Dave: Well, things were going real good... then one day she just Punky Brewstered on me and i havent seen her since.
by Dancendiary July 01, 2009
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2
To be abadoned by someone. As Punky Brewster was abadoned by her mother at a shopping center.
My buddies totally Punky Brewstered me last night at the party
I am gonna Punky Brewster this guy.
by Don't worry about it 8 December 26, 2013
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