A state of permanent crankiness; generally onset after continuous demoralization and disenfranchisement of an individual or group, in a workplace or household.
"What is up with Joetoday?" ~ "He's permacranked, man."
Permadrunk occurs when one has consumed a large amount of alcohol, wake up drunk the next morning, and start their day without sleeping off the drunkenness. This person will now be permadrunk and feel slightly intoxicated throughout the entirety of the day.
Dude, you better go back to sleep otherwise you're gonna be permadrunk all day.