p.o.y.s. Share definition Flag Pissing Out Your Shitter "Man, I drank so much Saturday night, I had the P.O.Y.S. for two days" p.o.y.s. by ricflairismyfather October 4, 2005 0 0 Get merch Get the p.o.y.s. mug. Buy Now — $32.95 See more merch