Me Duh Share definition Flag One of the simplest jokes to accomplish referring to your (if a male) genitals. guy1: Yo, you got the 4-5-4 box? guy2: The what? guy1: Me duh! Me Duh by Philly_YoungBull215 April 27, 2009 0 0 Get merch Get the Me Duh mug. Buy Now — $32.95 See more merch