louisiana handshake Share definition Flag Sticking ones finger into anothers no-no areas, most likely the anus, and then pulling it out after a few seconds. Put 'er there and give me one a 'em Louisiana handskakes louisiana handshake by Sam March 3, 2005 0 0 Get merch Get the louisiana handshake mug. Buy Now — $32.95 See more merch