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The act of ejaculation or masturbation. Rooted from the trifecta of knuckles that surrounds the end of a penis during masturbation.
"Hey man I'll be over in like 5. Just gotta go knuckle-off a few."

"That girl was such a tease, but whatever. I'll just knuckle-off a few when I get home."

by AK!!! October 27, 2007
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